It is an multifactorial event that if attribute the extrsecos factors, related to the environment, and intrsecos that respect to the physical and cognitivo state of the person says. For (Martini, et al., 2009), the lack of consumption of milky derivatives and the constant alcoholic beverage use are amongst the risk factors more associates with low the ssea density. Other factors can also contribute for the sprouting of the illness, being able to relate beyond alcoholism; the sedentary life, the pollution, the water without fluorine and it estresse (REBELLATO; MORELLI, 2004). According to Smeltzer and Bare (2004), some individual factors are considered as raised age, initial ssea loss, low stature, coexistentes medical conditions and medicines, as well as, other factors of risk associates to the style of life between them the lack of exercises, poor diet in calcium and vitamin D, beyond the lack of exposition to the solar light at least 15 minutes every day. 2,7 Signals and Symptoms Know that people between 75 and 85 years of age that need aid for the daily tasks, have probability to fall 14 times bigger that the independent people of the same age. They is esteem that the falls cause 90% of the breakings of hip in aged, acometimento that presents high morbidade, mortality and costs for the public health (IT HISSES, et al., 2003, P. 497). Osteoporose has as main consequence the breaking that most of the time, can become serious, cause severe limitations socially, leaving the emotivo and reserved individual, compromising its quality of life, establishing a picture of anxiety, depression and changes of mood, leading the person to keep a style of sedentary life if being isolated socially, and with this preferring to be inside of house from fear to not only acquire other breakings, but also to prevent pain. Of this form, the biggest contribution for one pssima quality of life in aged people with osteoporose is the presence of breakings caused for the illness, and the illness (not only SAILS; OISHI, 2007).
The Adolescent and the Fatigue Dr. Wagner Paulon 10/2009 Very common a physical problem that occurs in such a way with the boys as with the girls during the puberty, is the fatigue, or lack of energy. Its body will be investing as much of its resources in the growth process that will seem to lack energy to it for other activities during a certain period of time. This phase generally does not last very. However, this sensation of fatigue is something that you must wait. In fact, it will have to influence its behavior in two ways. In first place you will have to sleep and to rest sufficiently during the period of fast physical growth.
This necessity nor always is satisfied, however, because the adolescents find that more do not have to go so early for the bed as when they were children. Thus being, they are of foot until afternoon and if they drag per the following day in an exhaustion state. It believes or not, a necessary person of twelve or thirteen years in the truth to rest simply more than what when had nine or ten years, because of acceleration in the growth. In case that its parents will be reading this Article, he would like to suggest that they left you to sleep in the mornings of Saturday, if possible. It is generally difficult parents to allow them that its grown son sleeps until 9h30 of the morning when the pertaining to school tasks need to be executed. However, they would have to know that it is in the necessary bed because of more sleep, and would have to be sufficiently wise to allow that he makes this.
It will be able then to carry through its pertaining to school duties when to wake up, with a smile of gratitude in the face! In according to place, the foods that to eat will be also very important during the adolescence. Its necessary body of the substance cousin to construct those new muscular cells, bones and staple fibres that are in the plans. Dog-hot, cooling biscuits and do not serve. It will be necessary that it has a diet balanced during this period; this is much more important of what when had six or eight years. If not to eat right during this period of growth, it will go to pay to the price in form of illnesses and some physical problems. Its necessary body of vitamins you leave minerals and proteins necessary to develop themselves in some ways.
The molecule of frutose originated of the diet, when entering in citosol cellular of the liver or the esqueltico estriado muscle, is fosforilada frutose 1 P for the enzyme fosfofrutoquinase 1. Already frutose originated of the glucose, suffers to isomerisao for the enzyme glicoisomerase if becoming F6P, and later it suffers fosforilao for enzyme PFK in carbon 1 (C1), being thus prepared to give to continuity the metabolic cascade for attainment of energy (AZEVEDO et al., 2009; MIRES et al., 2005). This molecule is an isomer of the glucose molecule, and if they differ for the fact from the glucose to be one aldo-hexose and frutose one ceto-hexose as it shows figure 3 (VOLLHARDT; SCHORE, 2004). Figure 2: glucose molecules and frutose, isomers between itself Figure 2: The demonstrated glucose molecules and frutose as isomeric. Source: VOLLHARDT; SCHORE, 2004 3,3 Fosfofrutoquinase (PFK) the PFK is the enzyme of bigger importance, control and regulation of the glicoltica way, catalyzing the third step of this saw, being irreversible it in physiological conditions (NCBI, 2011; STRYER, 1996). This enzyme possesss four identical subunidades (tetrmero) called tetrmero as if it observes in figure 4.
Its regulation if makes in alostrica way, for feedback, through the ATP concentrations and citrate that when they are increased promotes reduction even though or inhibition of the activity of this enzyme. The PFK is found in two isoformas, is M and L, muscular and heptica respectively. In the two hemcias isoformas are operating (CAMPBELL, 2006; NCBI, 2011; STRYER, 1996). When the specific gene of isoforma M is not had, gliclise occurs only in the liver and the hemcias, thus producing muscular weakness. The gene that carries through this codification of the muscular PFK if finds in the number chromosome 12 (CAMPBELL, 2006; GARCI’A et al., 2009; TOSCANO, 2009). Figure 3: Fosfofrutoquinase showing its catalytic and alostricos small farms Source: This deficiency of the PFK in the muscular cells, as well as in the other cells of the organism, generates interruption of the third and more important step of the glicoltica way.